Long Noncoding RNA: its partners and their roles in cancer

Z. LIN, Y. HU, S. LAI, M. XUE, J. LIN, Y. QIAN, W. ZHUO, S. CHEN, J. SI, L. WANG

Abstract:

RNA transcripts, which do not encode proteins, have received considerable attention in recent years. These non-coding RNAs are classified into two groups: small non-coding RNAs and long non-coding RNAs (lncRNAs). Increasing evidence suggests that lncRNAs are emerging as key regulators in many biological processes. However, knowledge of the underlying mechanisms whereby they act is still limited. Here, we try to elucidate the way that lncRNAs function in the context of DNA, RNA and protein interaction networks. It is noteworthy that lncRNA and another type of non-coding RNA microRNA (miRNA) may ‘talk’ to each other more frequently than ever expected. Additionally, lncRNAs display aberrant expression profiles in different kinds of cancers, with their potential roles in carcinogenesis and cancer metastasis. We summarize the effect of some cancer related lncRNAs upon tumor biological events, including cell proliferation, apoptosis, invasion and metastasis. Finally, we focus on the clinical value of lncRNAs, considering their potential application in cancer diagnosis, prognosis and therapeutic intervention.