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Deep inside of gastric signet-ring cell carcinoma

 Luca Roncati, Antonio Manenti, Giuseppe Barbolini, Antonio Maiorana

Abstract:

The histology of signet-ring cell carcinoma (SRC) of the stomach has been revisited with the support of current immunohistochemical techniques in order to explain particular features of this tumor; its great capacity of local diffusion and lymph node metastasis, also through a neo-lymphoangiogenesis. An observational retrospective study on 50 cases of SRC in stage II and III has been performed with the addition of histochemical (Alcian Blue, DDD-Fast Blue B, Mercury Orange) and immunohistochemical (cytocheratin, CD3, CD4, CD8, CD10, CD56, CD68, perforin, granzyme B, podoplanin, collagen type IV) investigations for each case. The signet ring cells, typical for this tumor, show abundant content of electro-negative sialomucins and demonstrate a great capacity of diffusion through the gastric wall. They evoke production and deposition of collagen type IV in the sub-mucosa layer through the local action of fibroblasts. The immunological response to this tumor in the gastric wall and in the metastatic lymph nodes is represented by an increase of B and T-helper lymphocytes, but not of T-killers or natural killers. The neoplastic cells are curiously able to avoid these newly formed 'lymph nodules'. An extended neo-lymphangiogenesis has been observed around the primary tumor and in metastatic lymph nodes. A careful immunohistochemical characterization has allowed a better knowledge of SRC, regarding especially the peculiar behavior of local diffusion of its cells, the associated neo-lymph angiogenesis, and poor immunological reaction.

Received date: 04/05/2017

Accepted date: 09/27/2017

Ahead of print publish date: 07/30/2018

Issue: 4/2018

Volume: 65

Pages: 579 — 584

Keywords: undifferentiated gastric carcinoma, signet-ring cell carcinoma, lymphangiogenesis, tumour-infiltrating lymphocytes, cancer, histology

DOI: 10.4149/neo_2018_170404N246

Pubmed

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