Bactericidal capacity of platelets in gastric cancer patients
Abstract:
The aim of this study was to evaluate bactericidal capacity of platelets in patients suffering from gastric cancer. Number of platelets and their bactericidal activity were measured in 32 cancer patients (divided into 2 groups: I -- resectable cancer, II -- non-resectable one) and 32 normal donors. In group I the number of platelets was 259.136±84.459 x 103/µl. It was increased comparing to the normal donors 193.219±55.493 x 103/µl. After the surgery increase in platelet number was observed (472.05±111.772 x 103/µl). In group II an increased number of platelets was observed (265.1±81.813 x 103/µl) and it was maintained in a post-operative period: 234.2±54.141 x 103/µl. In group I bactericidal capacity of platelets was 2.25±7.33%, whereas it increased significantly after the surgery -- 4.7±7.46%. In group II, it was 8.6±17.61% before and 4.72±4.76% after the surgery. In normal donors this ability was 21.66±16.66. In gastric cancer patients increased platelet number was observed. Significant increase in platelets number occured after a radical tumor removal. Decreased bactericidal activity of platelets was noticed in gastric cancer patients. After surgical removal of the tumor, platelets partly reclaimed bactericidal capacity. In patients presenting disseminated gastric cancer, bactericidal capacity of platelets could be permanently impaired.