MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression

Tang-Bin Hu,  Hong-Shen Chen, Ming-Qian Cao, Fang-Dong Guo, Xiao-Yu Cheng, Zhong-Bin Han, Mo-Qiang Li

Abstract:

Breast cancer is one of the most prevalent and fatal diseases around the world. The mechanism of tumorigenesis in breast cancer remains to be clarified. miR-421 plays an oncogenic roles in many cancers. But the clinical significance of miR-421 in patients with breast cancer is still to be investigated. Caspase-10 is one of the initiator in apoptosis. But the relationship between miR-421 and caspase-10 has not been investigated. In the present study, we found that miR-421 was expressed much higher in breast cancer tissues compared with those in adjacent non-tumor tissues. Furthermore, miR-421 promotes cell proliferation and colony formation in vitro. miR-421 inhibits cell apoptosis probably through restraining caspase-10 expression. Thus, miR-421 might be a potential diagnostic maker and therapeutic target for breast cancer.