FBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway

Hai-Yan Mao, Si-Ping Liu, Gui-Mei Kong, Yuan Xu, Yong-Chen Xu, Guo-Zhuang Sun, Zhu Wang, Fang Han,  Jian-Dong Tong,  Ping Bo

Abstract:

Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA could inhibit proliferation, induce G1/S arrest, and promote cell apoptosis. Fibulin-3 overexpression further suppressed the invasion and metastasis of CRC. These effects were regulated through the AKT/mTOR signaling pathway.