Vitamin D receptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: a meta-analysis
Abstract:
The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer.A total of 32 comparative studies were evaluated in this meta-analysis, which included 17,067 patients and 20,843 controls. Meta-analysis of the VDR FokI polymorphism indicated an association between the incidence of breast cancer and the ff genotype in Europeans (OR = 1.126, 95% CI = 1.026–1.243, p = 0.019). Furthermore, an association between the incidence of breast cancer and the VDR FokI polymorphism was found in the Europeans using the allele contrast, as well as the homozygote contrast. However, the meta-analysis indicated no association between breast cancer and the BsmI polymorphism in all study subjects, including the Europeans (OR for the B allele = 0.996, 95% CI = 0.964–1.097, p = 0.930, 1.026, 95% CI = 0.929–1.134, p = 0.610). Moreover, breast cancer incidence was not associated with the ApaI and Taq polymorphisms (OR for the A allele = 0.908, 95% CI = 0.763–1.041, p = 0.167, OR for the T allele = 0.972, 95% CI = 0.929–1.017, p = 0.221).This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to breast cancer in the European population.