Antioxidant defense system in prostate adenocarcinoma and benign prostate hyperplasia of elderly patients
Abstract:
Prostate adenocarcinoma (PC) and benign prostate hyperplasia (BPH) are age-related diseases. The augmented oxidative stress is suggested to play an important role in the pathogenesis of both mentioned prostate disorders. In the presented study the antioxidant defense system in PC and BPH patients has been evaluated. The study was carried out on 30 PC patients (age 61±8 years) and 30 BPH patients (age 63±8 years). The control group consisted of 25 healthy men (age 61±14 years). The reduced glutathione (GSH) concentrations in the erythrocytes and the activities of plasma superoxide dismutase (EC-SOD), plasma glutathione peroxidase (GPx-3), erythrocyte glutathione peroxidase (GPx-1) and erythrocyte glutathione S-transferase (GST) were measured in the examined groups. GSH concentrations in the erythrocytes and plasma GPx-3 activities in the PC group (2.31±0.27 mmol/l and 186.2±39 U/l, respectively) were significantly lower (P