The association between LncRNA HOTAIR and cancer lymph node metastasis and distant metastasis: a meta-analysis

Zhe Sun, Xiao-Ying Wu,  Cheng-Liang Wu

Abstract:

HOTAIR has been reported to be associated with the development and metastasis in different types of cancer. This meta-analysis collected all relevant articles and explored the correlation of HOTAIR with lymph node metastasis (LNM) and distant metastasis (DM). A literature collection was conducted by searching PubMed, Web of Science, Google Scholar and Cochrane Library (up to sep 11, 2016). The odds ratio (OR) with 95% confidence interval (95%CI) was calculated to assess the association on strength. Nineteen studies were included in this study, with a total of 1874 patients. The study objects were all Asians. We found high HOTAIR expression in tumor tissues was significantly correlated with LNM and DM, and analysis showed a pooled OR of 3.18 (95%CI: 2.10-4.81, p<0.00001) and 3.93 (95%CI: 2.39-6.47, p<0.00001), respectively. HOTAIR may serve as a novel diagnostic biomarker for cancer metastasis.