Ste20-like kinase is upregulated in glioma and induces glioma invasion

Kun Wang, Rui-Long Hong, Jin-Biao Lu,  Dong-Lin Wang

Abstract:

The malignant development and poor prognosis of gliomas are associated with the high degree of invasion and high recurrence rate. However, the molecular mechanism underlying the invasiveness of glioma remains to be elucidated. Ste20-like kinase (SLK) is one of the members of the Ste20 family, which has been implicated in cellular migration and invasion. In this study, we intended to explore the expression of SLK significantly related to clinicopathologic stages of gliomas. Immunohistochemical staining and western blot analysis demonstrated that SLK was highly expressed in human glioma tissues and cell lines. Kaplane-Meier analysis revealed that poor survival was associated with high SLK expression. The inhibition of SLK by RNA interference significantly suppressed the invasion ability of glioma, and on protein level, knockdown of SLK leaded to an up-regulation of E-cadherin and a down-regulation of Vimentin in glioma cells. Collectively, these research shed light on mechanisms of invasion and progression of malignant gliomas and suggested that SLK may be a potential therapeutic strategy for glioma.