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Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression

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Xian-Qi Feng, Shu-Min Nie, Jun-Xia Huang, Tian-Lan Li, Jing-Jing Zhou, Wei Wang,  Li-Kun Zhuang,  Fan-Jun Meng

Abstract:

Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.

Received date: 11/29/2018

Accepted date: 06/04/2019

Ahead of print publish date: 06/29/2019

Issue: 1/2020

Volume: 67

Pages: 171 — 177

Keywords: chronic myeloid leukemia, circRNAs, outcome, miR-124

DOI: 10.4149/neo_2018_181129N908

Pubmed

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